New Real-time Dynamic Monitoring for Echo® Liquid Handlers Enables Expanded Fluid Types and Applications 03 Sep 2010: Surfactants and proteins are key components in biological assays, yet historically they have been difficult to dispense with high-speed tip- or nozzle-based liquid handling instrumentation. This poster explains exciting new developments for Labcyte Echo liquid handlers that provide real-time fluid monitoring to ensure precise and accurate dispensing for a wide range of fluid types and applications. Labcyte
Recent articles:
Characterization of Ion Channels in Stem Cell-derived Cardiomyocytes on An Automated Parallel Patch Clamp System 22 Jun 2010: In this application note Molecular Devices use the PatchXpress 7000A automated parallel patch clamp system is used to record Na, K and Ca currents from stem cell-derived mouse cardiomyocytes. The collaborative effort demonstrates that the combination of “ready-to-use” cardiomyocytes with an automated patch clamp system offers a powerful assay platform for fast assessment of compound efficacy and for safety profiling of lead compounds in a biologically relevant system. Molecular Devices
Stem Cell-Derived Human Neurons in CNS Drug Discovery 07 Jun 2010: In this application note from Molecular Devices reproducible batches of human neurons are generated that will significantly improve and impact CNS drug discovery. The stem cell-derived neurons express all known markers typically associated with mature neurons and are functionally active. These neurons have been used in a recent screen to identify antagonists of a novel GPCR target implicated in schizophrenia. Molecular Devices
Cytotoxicity in Cells: Easy Determination Using Lonza ViaLight Plus and ToxiLight BioAssays on the SpectraMax L Microplate Luminometer 07 Jun 2010: The Lonza ViaLight® Plus and ToxiLight® Bioluminescent Cytotoxicity Assays exploit the cell characteristics of ATP levels and adenylate kinase release respectively, as cytotoxicity measures and enable detection using bioluminescent methods. This application note demonstrates that the SpectraMax L Microplate Luminometer and SoftMax Pro Software from Molecular Devices combine well with both assays providing a fast and sensitive combination of technologies in the field of cell death. Molecular Devices
Using EL406™ Combination Washer Dispenser to Semi-Automate an ELISA for Melamine 24 May 2010: Melamine is a nitrogen rich compound that has been used illegally as an additive that mimics protein in foods. This application note demonstrates the ability of the EL406 to automate the liquid handling tasks required to run the melamine ELISA kit from Abraxis. The melamine ELISA has the capability to detect melamine contamination in the parts per billion (PPB) ranges. BioTek Instruments, Inc.
Electroporation of Smooth Muscle Cells Using the Gene Pulser MXcell Electroporation System 06 May 2010: In this application note, Bio-Rad optimizes experimental conditions for transfection of several different smooth muscle cell (SMC) types using the Gene Pulser MXcell electroporation system. Electroporation parameters were optimized based on SMC viability and transfection efficiency. Different SMC types showed differential responses to varying voltage and capacitance. The system allows multiple cell types to be simultaneously tested in one single experiment. Bio-Rad Laboratories, Inc.
Nephelometric Monitoring Growth of Candida albicans Using BMG LABTECH’s NEPHELOstar 08 Apr 2010: Laser nephelometry has been shown to be a reliable technique for the measurement of drug solubility in 96-well plate format. In this application note the effects of complexation on drug antimycotic activity is described. Laser nephelometry can distinguish between the concentration at which the drug just goes into or just comes out of solution. This is presented in phase solubility studies. BMG LABTECH
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